Species : |
Human |
Source : |
Wheat Germ |
Tag : |
Non |
Protein Length : |
522 amino acids |
Description : |
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. |
Molecular Weight : |
83.530kDa inclusive of tags |
Tissue specificity : |
Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis. |
Form : |
Liquid |
Purity : |
Proprietary Purification |
Storage buffer : |
pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione |
Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : |
MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLS QPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIF ACVASTLAWDRGYGTSLLGGSVGYPYGGSGFGSYGSGYGY GYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSV IRSEMSRTRRYYLSVIIVSAILGIMVFIATIVYIMGVNPT AQSSGSLYGSQIYALCNQFYTPAATGLYVDQYSYHYCVVD PQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNIL WDKEHIYDEQPPNVEEWVKNVSAGTQDVPSPPSDYVERVD SPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPV DDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYET DYTTGGESCDELEEDWIREYPPITSDQQRQLYKRNFDTGL QEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADE YNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQ KT |
Sequence Similarities : |
Belongs to the ELL/occludin family.Contains 1 MARVEL domain. |