Recombinant Human OCLN protein, MYC/DDK-tagged

• Cat.No.: OCLN-3603H
• Product Overview: Recombinant Human OCLN, fussed with MYC/DDK tag at C-terminal, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 59 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: OCLN occludin [ Homo sapiens ]
• Official Symbol: OCLN
• Synonyms: OCLN; occludin; tight junction protein occludin TM4 minus; tight junction protein occludin; BLCPMG; FLJ08163; FLJ18079; FLJ77961; FLJ94056; MGC34277
• Gene ID: 100506658
• mRNA Refseq: NM_002538
• Protein Refseq: NP_002529
• MIM: 602876
• UniProt ID: Q16625
• Chromosome Location: 5q13.1
• Pathway: Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Leukocyte transendothelial migration, organism-specific biosystem; Leukocyte transendothelial migration, conserved biosystem; Pathogenic Escherichia coli infection, organism-specific biosystem
• Function: protein binding; structural molecule activity; thiopurine S-methyltransferase activity