Recombinant Human OGDH protein, MYC/DDK-tagged

• Cat.No.: OGDH-562H
• Product Overview: Recombinant Human OGDH, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 111.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) [ Homo sapiens ]
• Official Symbol: OGDH
• Synonyms: OGDH; oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide); 2-oxoglutarate dehydrogenase, mitochondrial; E1k; OGDC-E1; oxoglutarate decarboxylase; 2-oxoglutarate dehydrogenase complex component E1; oxoglutarate dehydrogenase (succinyl-transferring); OGDC; AKGDH
• Gene ID: 4967
• mRNA Refseq: NM_002541
• Protein Refseq: NP_002532
• MIM: 613022
• UniProt ID: Q02218
• Chromosome Location: 7p13-p11.2
• Pathway: 2-ketoglutarate dehydrogenase complex, organism-specific biosystem; 2-ketoglutarate dehydrogenase complex, conserved biosystem; Citrate cycle (TCA cycle), organism-specific biosystem; Citrate cycle (TCA cycle), conserved biosystem; Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate, organism-specific biosystem; Citrate cycle, second carbon oxidation, 2-oxoglutarate =>
• Function: oxidoreductase activity; oxoglutarate dehydrogenase (NAD+) activity; oxoglutarate dehydrogenase (succinyl-transferring) activity; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding