Recombinant Human OMA1 Protein, His-tagged
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| Cat.No. : | OMA1-10H |
| Product Overview : | Recombinant human OMA1 protein (217-524) with a N-teminus His-tag was expressed in E. coli. |
| Description : | OMA1 is an ATP-independent metalloproteinase encoded by OMA1. It is localized to the mitochondrial inner membrane and is comprised of a matrix-facing N-terminal domain, a transmembrane domain, and a C-terminal M48 metallopeptidase domain that is exposed to the intermembrane space. Under various stress conditions, including oxidative stress, heat stress, and mitochondrial membrane depolarization, OMA1 is activated and cleaves long isoforms of the GTPase optic atrophy 1 (OPA1) at the S1 cleavage site, leading to inhibition of mitochondrial fusion and increased mitochondrial fragmentation.Under stress conditions, OMA1 is also autocatalytically degraded, thereby limiting, and allowing for reversal of, the stress response. Oma1-/- mouse embryonic fibroblasts exhibit a loss of mitochondrial fragmentation upon exposure to hydrogen peroxide. Mice lacking Oma1 exhibit impaired thermogenesis, increased hepatic steatosis and serum triglyceride levels, and high-fat diet-induced obesity. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His |
| Form : | 50 mM Tris, pH 8.0, with 150 mM sodium chloride, 10% glycerol, 0.5 mL-arginine, and 2 μM zinc chloride |
| Molecular Mass : | 37.1 kDa |
| Protein length : | 217-524 |
| Purity : | ≥90% estimated by SDS-PAGE |
| Applications : | WB, ELISA |
| Stability : | Samples are stable for up to one year from date of receipt at -80 centigrade. |
| Storage : | Store at -80 centigrade |
| SDS-PAGE of OMA1 : |
Lane 1: MW Markers, Lane 2: Metalloendopeptidase OMA1(4 µg), Lane 3: Metalloendopeptidase OMA1(2 µg), Representative gel image shown; actual purity may vary between each batch. |
| Gene Name : | OMA1 OMA1 zinc metallopeptidase [ Homo sapiens (human) ] |
| Official Symbol : | OMA1 |
| Synonyms : | OMA1; OMA1 zinc metallopeptidase; DAB1; MPRP1; MPRP-1; YKR087C; ZMPOMA1; peptidase; 2010001O09Rik; metalloendopeptidase OMA1, mitochondrial; OMA1 homolog, zinc metallopeptidase; OMA1 zinc metallopeptidase homolog; metalloprotease-related protein 1; overlapping activity with M-AAA protease; overlapping with the m-AAA protease 1 homolog; zinc metallopeptidase OMA1 |
| Gene ID : | 115209 |
| mRNA Refseq : | NM_145243 |
| Protein Refseq : | NP_660286 |
| MIM : | 617081 |
| UniProt ID : | Q96E52 |
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