Recombinant Human OMA1 Protein, His-tagged
Cat.No. : | OMA1-036H |
Product Overview : | Recombinant N-terminal His-tagged OMA1 human protein (217-524) was expressed in E. coli. |
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- Gene Information
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Description : | Metalloprotease that is part of the quality control system in the inner membrane of mitochondria (PubMed:20038677, PubMed:25605331, PubMed:32132706, PubMed:32132707). Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1 (PubMed:20038677, PubMed:25275009, PubMed:32132706, PubMed:32132707). Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion (PubMed:20038677, PubMed:25275009). Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae (PubMed:25275009). In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome (PubMed:30733118). May also cleave UQCC3 in response to mitochondrial depolarization (PubMed:25605331). Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (PubMed:32132706, PubMed:32132707). Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (By similarity). Binds cardiolipin, possibly regulating its protein turnover (By similarity). Required for the stability of the respiratory supercomplexes (By similarity). |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | 37.1 kDa |
Protein length : | 217-524 |
Purity : | ≥90% |
Applications : | WB, ELISA |
Stability : | ≥ 1 year |
Storage : | At -80 centigrade. |
Storage Buffer : | 50 mM Tris, pH 8.0, with 150 mM sodium chloride, 10% glycerol, 0.5 M L-arginine, and 2 μM zinc chloride |
Gene Name : | OMA1 OMA1 zinc metallopeptidase [ Homo sapiens (human) ] |
Official Symbol : | OMA1 |
Synonyms : | OMA1; OMA1 zinc metallopeptidase; DAB1; MPRP1; MPRP-1; YKR087C; ZMPOMA1; peptidase; 2010001O09Rik; metalloendopeptidase OMA1, mitochondrial; OMA1 homolog, zinc metallopeptidase; OMA1 zinc metallopeptidase homolog; metalloprotease-related protein 1; overlapping activity with M-AAA protease; overlapping with the m-AAA protease 1 homolog; zinc metallopeptidase OMA1 |
Gene ID : | 115209 |
mRNA Refseq : | NM_145243 |
Protein Refseq : | NP_660286 |
MIM : | 617081 |
UniProt ID : | Q96E52 |
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OMA1-01H | Recombinant Human OMA1 Protein, His-tagged | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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