| Description : |
The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
109.4 kDa |
| AA Sequence : |
MWRLRRAAVACEVCQSLVKHSSGIK GSLPLQKLHLVSRSIYHSHHPTLKL QRPQLRTSFQQFSSLTNLPLRKLKF SPIKYGYQPRRNFWPARLATRLLKL RYLILGSAVGGGYTAKKTFDQWKDM IPDLSEYKWIVPDIVWEIDEYIDFG HKLVSEVIGASDLLLLLGSPEETAF RATDRGSESDKHFRKVSDKEKIDQL QEELLHTQLKYQRILERLEKENKEL RKLVLQKDDKGIHHRKLKKSLIDMY SEVLDVLSDYDASYNTQDHLPRVVV VGDQSAGKTSVLEMIAQARIFPRGS GEMMTRSPVKVTLSEGPHHVALFKD SSREFDLTKEEDLAALRHEIELRMR KNVKEGCTVSPETISLNVKGPGLQR MVLVDLPGVINTVTSGMAPDTKETI FSISKAYMQNPNAIILCIQDGSVDA ERSIVTDLVSQMDPHGRRTIFVLTK VDLAEKNVASPSRIQQIIEGKLFPM KALGYFAVVTGKGNSSESIEAIREY EEEFFQNSKLLKTSMLKAHQVTTRN LSLAVSDCFWKMVRESVEQQADSFK ATRFNLETEWKNNYPRLRELDRNEL FEKAKNEILDEVISLSQVTPKHWEE ILQQSLWERVSTHVIENIYLPAAQT MNSGTFNTTVDIKLKQWTDKQLPNK AVEVAWETLQEEFSRFMTEPKGKEH DDIFDKLKEAVKEESIKRHKWNDFA EDSLRVIQHNALEDRSISDKQQWDA AIYFMEEALQARLKDTENAIENMVG PDWKKRWLYWKNRTQEQCVHNETKN ELEKMLKCNEEHPAYLASDEITTVR KNLESRGVEVDPSLIKDTWHQVYRR HFLKTALNHCNLCRRGFYYYQRHFV DSELECNDVVLFWRIQRMLAITANT LRQQLTNTEVRRLEKNVKEVLEDFA EDGEKKIKLLTGKRVQLAEDLKKVR EIQEKLDAFIEALHQEKSGPTRTRR LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
