Recombinant Human OTUD5 Protein (G172-G351), His/Flag tagged

• Cat.No.: OTUD5-0376H
• Product Overview: Recombinant Human 6His-TEV-GG-OTUD5(G172-G351)-Flag Protein was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Flag&His
• Protein Length: G172-G351
• Description: Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1.
• Form: Liquid
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: OTUD5 OTU domain containing 5 [ Homo sapiens (human) ]
• Official Symbol: OTUD5
• Synonyms: DUBA
• Gene ID: 55593
• mRNA Refseq: NM_017602
• Protein Refseq: NP_060072
• MIM: 300713
• UniProt ID: Q96G74