Recombinant Human PDE4B Protein, His/GST-tagged PDE4B-09H

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Recombinant Human PDE4B Protein, His/GST-tagged

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Cat.No. :	PDE4B-09H
Product Overview :	Recombinant human PDE4B protein (1-564) with a N-terminal His/GST-tag was expressed in insect cells.
Description :	This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.
Source :	Insect cell
Species :	Human
Tag :	His/GST
Form :	Lyophilized from sterile 50 mM Tris, pH 8.0, with 100 mM sodium chloride, 0.5 mM GSH, 10% gly, and 0.5 mM PMSF
Molecular Mass :	92.2 kDa
Protein length :	1-564
Endotoxin :	<1.0 EU/μg, determined by the LAL endotoxin assay
Purity :	≥80% estimated by SDS-PAGE
Stability :	≥ 1 year
Storage :	Store at -80 centigrade
SDS-PAGE Analysis of PDE4B2 :	Lane 1: MW Markers, Lane 2: PDE4B2. SDS-PAGE Analysis of PDE4B2. This protein has a calculated molecular weight of 92.2 kDa. It has an apparent molecular weight of approximately 100 kDa by SDS-PAGE under reducing condions.

Gene Name :	PDE4B phosphodiesterase 4B [ Homo sapiens (human) ]
Official Symbol :	PDE4B
Synonyms :	PDE4B; phosphodiesterase 4B; DPDE4; PDEIVB; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; dunce-like phosphodiesterase E4; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
Gene ID :	5142
mRNA Refseq :	NM_001037339
Protein Refseq :	NP_001032416
MIM :	600127
UniProt ID :	Q07343