| Description : |
This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
57.1 kDa |
| AA Sequence : |
MTSTFNPRECKLSKQEGQNYGFFLR IEKDTEGHLVRVVEKCSPAEKAGLQ DGDRVLRINGVFVDKEEHMQVVDLV RKSGNSVTLLVLDGDSYEKAVKTRV DLKELGQSQKEQGLSDNILSPVMNG GVQTWTQPRLCYLVKEGGSYGFSLK TVQGKKGVYMTDITPQGVAMRAGVL ADDHLIEVNGENVEDASHEEVVEKV KKSGSRVMFLLVDKETDKRHVEQKI QFKRETASLKLLPHQPRIVEMKKGS NGYGFYLRAGSEQKGQIIKDIDSGS PAEEAGLKNNDLVVAVNGESVETLD HDSVVEMIRKGGDQTSLLVVDKETD NMYRLAHFSPFLYYQSQELPNGSVK EAPAPTPTSLEVSSPPDTTEEVDHK PKLCRLAKGENGYGFHLNAIRGLPG SFIKEVQKGGPADLAGLEDEDVIIE VNGVNVLDEPYEKVVDRIQSSGKNV TLLVCGKKAYDYFQAKKIPIVSSLA DPLDTPPDSKEGIVVESNHDSHMAK ERAHSTASHSSSNSEDTEMTRTRPL EQKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
