| Description : |
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
70.6 kDa |
| AA Sequence : |
MSGQSLTDRITAAQHSVTGSAVSKT VCKATTHEIMGPKKKHLDYLIQCTN EMNVNIPQLADSLFERTTNSSWVVV FKSLITTHHLMVYGNERFIQYLASR NTLFNLSNFLDKSGLQGYDMSTFIR RYSRYLNEKAVSYRQVAFDFTKVKR GADGVMRTMNTEKLLKTVPIIQNQM DALLDFNVNSNELTNGVINAAFMLL FKDAIRLFAAYNEGIINLLEKYFDM KKNQCKEGLDIYKKFLTRMTRISEF LKVAEQVGIDRGDIPDLSQAPSSLL DALEQHLASLEGKKIKDSTAASRAT TLSNAVSSLASTGLSLTKVDEREKQ AALEEEQARLKALKEQRLKELAKKP HTSLTTAASPVSTSAGGIMTAPAID IFSTPSSSNSTSKLPNDLLDLQQPT FHPSVHPMSTASQVASTWGDPFSAT VDAVDDAIPSLNPFLTKSSGDVHLS ISSDVSTFTTRTPTHEMFVGFTPSP VAQPHPSAGLNVDFESVFGNKSTNV IVDSGGFDELGGLLKPTVASQNQNL PVAKLPPSKLVSDDLDSSLANLVGN LGIGNGTTKNDVNWSQPGEKKLTGG SNWQPKVAPTTAWNAATMAPPVMAY PATTPTGMIGYGIPPQMGSVPVMTQ PTLIYSQPVMRPPNPFGPVSGAQIQ FMTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
