| Description : |
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
101.4 kDa |
| AA Sequence : |
MGEAEKFHYIYSCDLDINVQLKIGS LEGKREQKSYKAVLEDPMLKFSGLY QETCSDLYVTCQVFAEGKPLALPVR TSYKAFSTRWNWNEWLKLPVKYPDL PRNAQVALTIWDVYGPGKAVPVGGT TVSLFGKYGMFRQGMHDLKVWPNVE ADGSEPTKTPGRTSSTLSEDQMSRL AKLTKAHRQGHMVKVDWLDRLTFRE IEMINESEKRSSNFMYLMVEFRCVK CDDKEYGIVYYEKDGDESSPILTSF ELVKVPDPQMSMENLVESKHHKLAR SLRSGPSDHDLKPNAATRDQLNIIV SYPPTKQLTYEEQDLVWKFRYYLTN QEKALTKFLKCVNWDLPQEAKQALE LLGKWKPMDVEDSLELLSSHYTNPT VRRYAVARLRQADDEDLLMYLLQLV QALKYENFDDIKNGLEPTKKDSQSS VSENVSNSGINSAEIDSSQIITSPL PSVSSPPPASKTKEVPDGENLEQDL CTFLISRACKNSTLANYLYWYVIVE CEDQDTQQRDPKTHEMYLNVMRRFS QALLKGDKSVRVMRSLLAAQQTFVD RLVHLMKAVQRESGNRKKKNERLQA LLGDNEKMNLSDVELIPLPLEPQVK IRGIIPETATLFKSALMPAQLFFKT EDGGKYPVIFKHGDDLRQDQLILQI ISLMDKLLRKENLDLKLTPYKVLAT STKHGFMQFIQSVPVAEVLDTEGSI QNFFRKYAPSENGPNGISAEVMDTY VKSCAGYCVITYILGVGDRHLDNLL LTKTGKLFHIDFGYILGRDPKPLPP PMKLNKEMVEGMGGTQSEQYQEFRK QCYTAFLHLRRYSNLILNLFSLMVD ANIPDIALEPDKTVKKVQDKFRLDL SDEEAVHYMQSLIDESVHALFAAVV EQIHKFAQYWRKTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
