Recombinant Human PITX2 Protein, HIS-tagged

• Cat.No.: PITX2-135H
• Product Overview: Recombinant Human PITX2, transcript variant 2, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl. Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Molecular Mass: 35.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: PITX2 paired-like homeodomain 2 [ Homo sapiens ]
• Official Symbol: PITX2
• Synonyms: PITX2; paired-like homeodomain 2; IHG2, IRID2, paired like homeodomain transcription factor 2 , RGS, RIEG, RIEG1; pituitary homeobox 2; ARP1; Brx1; IGDS; Otlx2; RS; solurshin; all1-responsive gene 1; homeobox protein PITX2; ALL1-responsive protein ARP1; paired-like homeodomain transcription factor 2; rieg bicoid-related homeobox transcription factor 1; RGS; IDG2; IHG2; PTX2; RIEG; IGDS2; IRID2; RIEG1; MGC20144; MGC111022
• Gene ID: 5308
• mRNA Refseq: NM_000325
• Protein Refseq: NP_000316
• MIM: 601542
• UniProt ID: Q99697