Recombinant Human Plasminogen
Cat.No. : | PLG-66H |
Product Overview : | Recombinant Human Angiostatin produced inPichia Pastorisis a single, non-glycosylated polypeptide chain having a molecular mass of 29711 Dalton. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PLG-66H |
Description : | RHuAng K1-3 is a proteolytic fragment of plasminogen containing the first three kringle structures. A specific inhibitor of endothelial cell growth and angiogenesis. More active relative to kringles 1-4. rHuAng K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth. The rHuAng K1-3 is purified by proprietary chromatographic techniques. |
Source : | Pichia Pastoris. |
Physical Appearance : | Sterile Filtered lyophilized powder. |
Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Anion-exchange FPLC. (c) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel. |
Formulation : | Lyophilized from a (1mg/ml) solution in containing 0.5X PBS. |
Solubility : | It is recommended to reconstitute the lyophilized rHuAng K1-3 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Biological Activity : | Inhibitory activity (ED50=70 nm) relative to Kringles 1-4 (ED50=135 nm). Kringles 1-3 acts as inhibitor of endothelial cell growth and angiogenesis. |
Endotoxin : | Less than 0.1 ng/µg (IEU/µg) of rHuAng K1-3. |
Protein Content : | Protein quantitation was carried out by two independent methods: 1. UV spectroscopy at 280 nm using the absorbency value of 2.08 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of rHuAng K1-3 as a Reference Standard. |
Storage : | Lyophilized rHuAng K1-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuAng K1-3 should be stored at 4°Cbetween 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | PLG plasminogen [ Homo sapiens ] |
Synonyms : | PLG; plasminogen; DKFZp779M0222; Plasminogen; Plasmin heavy chain A;Activation peptide; Angiostatin; Plasmin heavy chainA, short form; Plasmin light chain B;EC 3.4.21.7; OTTHUMP00000017544 |
Gene ID : | 5340 |
mRNA Refseq : | NM_000301 |
Protein Refseq : | NP_000292 |
MIM : | 173350 |
UniProt ID : | P00747 |
Chromosome Location : | 6q26 |
Pathway : | Complement and coagulation cascades; Neuroactive ligand-receptor interaction; Diabetes pathways; Hemostasis; Signaling by PDGF |
Function : | calcium ion binding; apolipoprotein binding; peptidase activity; serine-type endopeptidase activity |
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◆ Native Protein | ||
PLG-15H | Native Human Plasminogen Protein | +Inquiry |
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PLG-54H | Native Human glu-Plasminogen | +Inquiry |
◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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