Recombinant Human PLCE1 protein, MYC/DDK-tagged
Cat.No. : | PLCE1-356H |
Product Overview : | Recombinant Human PLCE1 fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 258.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | PLCE1 phospholipase C, epsilon 1 [ Homo sapiens ] |
Official Symbol : | PLCE1 |
Synonyms : | PLCE; PPLC; NPHS3; PLC-epsilon-1; pancreas-enriched phospholipase C; phosphoinositide phospholipase C-epsilon-1; phosphoinositide-specific phospholipase C epsilon-1 |
Gene ID : | 51196 |
mRNA Refseq : | NM_016341 |
Protein Refseq : | NP_057425 |
MIM : | 608414 |
UniProt ID : | Q9P212 |
Chromosome Location : | 10q23 |
Pathway : | Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; D-myo-inositol-5-phosphate metabolism, organism-specific biosystem |
Function : | Ras GTPase binding; enzyme binding; phospholipase C activity |
Products Types
◆ Recombinant Protein | ||
PLCE1-4164R | Recombinant Rat PLCE1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Plce1-4916M | Recombinant Mouse Plce1 Protein, Myc/DDK-tagged | +Inquiry |
PLCE1-6817M | Recombinant Mouse PLCE1 Protein, His (Fc)-Avi-tagged | +Inquiry |
PLCE1-1948H | Recombinant Human PLCE1 Protein, His&GST-tagged | +Inquiry |
PLCE1-7519Z | Recombinant Zebrafish PLCE1 | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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