Recombinant Human PLEKHA1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PLEKHA1-2827H
• Product Overview: PLEKHA1 MS Standard C13 and N15-labeled recombinant protein (NP_067635) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 45.6 kDa
• AA Sequence: MPYVDRQNRICGFLDIEENENSGKF LRRYFILDTREDSFVWYMDNPQNLP SGSSRVGAIKLTYISKVSDATKLRP KAEFCFVMNAGMRKYFLQANDQQDL VEWVNVLNKAIKITVPKQSDSQPNS DNLSRHGECGKKQVSYRTDIVGGVP IITPTQKEEVNECGESIDRNNLKRS QSHLPYFTPKPPQDSAVIKAGYCVK QGAVMKNWKRRYFQLDENTIGYFKS ELEKEPLRVIPLKEVHKVQECKQSD IMMRDNLFEIVTTSRTFYVQADSPE EMHSWIKAVSGAIVAQRGPGRSASS EHPPGPSESKHAFRPTNAATATSHS TASRSNSLVSTFTMEKRGFYESLAK VKPGNFKVQTVSPREPASKVTEQAL LRPQSKNGPQEKDCDLVDLDDASLP VSDVTRTRPLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PLEKHA1 pleckstrin homology domain containing A1 [ Homo sapiens (human) ]
• Official Symbol: PLEKHA1
• Synonyms: PLEKHA1; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; pleckstrin homology domain-containing family A member 1; tandem PH domain containing protein 1; TAPP1; tandem PH domain-containing protein 1
• Gene ID: 59338
• mRNA Refseq: NM_021622
• Protein Refseq: NP_067635
• MIM: 607772
• UniProt ID: Q9HB21