Recombinant Human POLE3, His-tagged

• Cat.No.: POLE3-7630H
• Product Overview: Recombinant human POLE3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 1-147aa
• Description: POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging. POLE3 has been shown to interact with SMARCA5.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 20% glycerol, 1mM DTT.
• Molecular Mass: 19kDa (170aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAERPED LNLPNAVITR IIKEALPDGV NISKEARSAI SRAASVFVLY ATSCANNFAM KGKRKTLNAS DVLSAMEEME FQRFVTPLKE ALEAYRREQK GKKEASEQKK KDKDKKTDSE EQDKSRDEDN DEDEERLEEE EQNEEEEVDN
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term. For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) [ Homo sapiens ]
• Official Symbol: POLE3
• Synonyms: POLE3; polymerase (DNA directed), epsilon 3 (p17 subunit); DNA polymerase epsilon subunit 3; arsenic transactivated protein; CHARAC17; CHRAC17; chromatin accessibility complex 17; DNA polymerase epsilon p17 subunit; histone fold protein CHRAC17; p17; Ybl1; asTP; CHRAC-17; huCHRAC17; DNA polymerase II subunit 3; arsenic-transactivated protein; DNA polymerase epsilon subunit p17; chromatin accessibility complex 17 kDa protein; YBL1
• Gene ID: 54107
• mRNA Refseq: NM_017443
• Protein Refseq: NP_059139
• MIM: 607267
• UniProt ID: Q9NRF9
• Chromosome Location: 9q33
• Pathway: Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; DNA polymerase epsilon complex, organism-specific biosystem; DNA replication, organism-specific biosystem; DNA replication, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem
• Function: DNA-directed DNA polymerase activity; nucleotidyltransferase activity; protein binding; sequence-specific DNA binding; transferase activity