| Description : |
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
78.2 kDa |
| AA Sequence : |
MATGQDRVVALVDMDCFFVQVEQRQ NPHLRNKPCAVVQYKSWKGGGIIAV SYEARAFGVTRSMWADDAKKLCPDL LLAQVRESRGKANLTKYREASVEVM EIMSRFAVIERASIDEAYVDLTSAV QERLQKLQGQPISADLLPSTYIEGL PQGPTTAEETVQKEGMRKQGLFQWL DSLQIDNLTSPDLQLTVGAVIVEEM RAAIERETGFQCSAGISHNKVLAKL ACGLNKPNRQTLVSHGSVPQLFSQM PIRKIRSLGGKLGASVIEILGIEYM GELTQFTESQLQSHFGEKNGSWLYA MCRGIEHDPVKPRQLPKTIGCSKNF PGKTALATREQVQWWLLQLAQELEE RLTKDRNDNDRVATQLVVSIRVQGD KRLSSLRRCCALTRYDAHKMSHDAF TVIKNCNTSGIQTEWSPPLTMLFLC ATKFSASAPSSSTDITSFLSSDPSS LPKVPVTSSEAKTQGSGPAVTATKK ATTSLESFFQKAAERQKVKEASLSS LTAPTQAPMSNSPSKPSLPFQTSQS TGTEPFFKQKSLLLKQKQLNNSSVS SPQQNPWSNCKALPNSLPTEYPGCV PVCEGVSKLEESSKATPAEMDLAHN SQSMHASSASKSVLEVTQKATPNPS LLAAEDQVPCEKCGSLVPVWDMPEH MDYHFALELQKSFLQPHSSNPQVVS AVSHQGKRNPKSPLACTNKRPRPEG MQTLESFFKPLTHTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
