Recombinant Human POLR2J3 Protein, MYC/DDK-tagged

• Cat.No.: POLR2J3-2453H
• Product Overview: Recombinant Human POLR2J3 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Description: This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 12.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 [ Homo sapiens ]
• Official Symbol: POLR2J3
• Synonyms: POLR2J2; RPB11b1; RPB11b2
• Gene ID: 548644
• mRNA Refseq: NM_001097615
• Protein Refseq: NP_001091084
• UniProt ID: Q9GZM3