"PPME1" Related Products

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Recombinant Human PPME1 protein, GST-tagged

Cat.No.: PPME1-195H
Product Overview: Recombinant Human PPME1(2-end) fused with GST tag at N-terminal was expressed in Insect cells.
Description: Protein phosphatase methylesterase 1 (PPME1) conducts the demethylation of the catalytic subunit of protein phosphatase 2A (PP2A) and leads to inactivation of the phosphatase. It is demonstrated that PPME1 binds directly to the active site of PP2A and evicts the manganese ions required for the phosphatase activity. PPME1 is also reported to protect ERK activity in human malignant glioma.
Source: Insect cells
Species: Human
Tag : GST
Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass: 70 kDa
Protein length: 2-end
Purity: >90%
Applications: Methyltransferase Assay
Stability: 1 year at -70 centigrade from the date of shipment
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: PPME1 protein phosphatase methylesterase 1 [ Homo sapiens ]
Official Symbol: PPME1
Synonyms: PPME1; protein phosphatase methylesterase 1; PME 1; protein phosphatase methylesterase-1; PME-1; FLJ22226;
Gene ID: 51400
mRNA Refseq: NM_016147
Protein Refseq: NP_057231
MIM: 611117
UniProt ID: Q9Y570
Chromosome Location: 11q13.4
Function: carboxylesterase activity; hydrolase activity; protein C-terminal methylesterase activity; protein phosphatase 2A binding; protein phosphatase binding; protein phosphatase inhibitor activity; protein phosphatase type 2A regulator activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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