Recombinant Human PSMA6 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PSMA6-4556H
• Product Overview: PSMA6 MS Standard C13 and N15-labeled recombinant protein (NP_002782) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 27.4 kDa
• AA Sequence: MSRGSSAGFDRHITIFSPEGRLYQV EYAFKAINQGGLTSVAVRGKDCAVI VTQKKVPDKLLDSSTVTHLFKITEN IGCVMTGMTADSRSQVQRARYEAAN WKYKYGYEIPVDMLCKRIADISQVY TQNAEMRPLGCCMILIGIDEEQGPQ VYKCDPAGYYCGFKATAAGVKQTES TSFLEKKVKKKFDWTFEQTVETAIT CLSTVLSIDFKPSEIEVGVVTVENP KFRILTEAEIDAHLVALAERDTRTR PLEQKLISEEDLAANDILDYKDDDD KV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PSMA6 proteasome 20S subunit alpha 6 [ Homo sapiens (human) ]
• Official Symbol: PSMA6
• Synonyms: PSMA6; proteasome (prosome, macropain) subunit, alpha type, 6; proteasome subunit alpha type-6; IOTA; MGC2333; MGC22756; MGC23846; p27K; PROS27; PROS-27; macropain iota chain; prosomal P27K protein; proteasome iota chain; macropain subunit iota; 27 kDa prosomal protein; proteasome subunit iota; multicatalytic endopeptidase complex iota chain
• Gene ID: 5687
• mRNA Refseq: NM_002791
• Protein Refseq: NP_002782
• MIM: 602855
• UniProt ID: P60900