Recombinant Human PSMC6 Protein, His-tagged

• Cat.No.: PSMC6-259H
• Product Overview: Recombinant Human PSMC6 fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
• Molecular Mass: 44 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 [ Homo sapiens ]
• Official Symbol: PSMC6
• Synonyms: PSMC6; proteasome (prosome, macropain) 26S subunit, ATPase, 6; 26S protease regulatory subunit 10B; p42; proteasome subunit p42; proteasome 26S subunit ATPase 6; conserved ATPase domain protein 44; 26S protease regulatory subunit S10B; 26S proteasome AAA-ATPase subunit RPT4; P44; SUG2; CADP44; MGC12520
• Gene ID: 5706
• mRNA Refseq: NM_002806
• Protein Refseq: NP_002797
• MIM: 602708
• UniProt ID: P62333