| Description : |
This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
58.6 kDa |
| AA Sequence : |
MMLRGNLKQVRIEKNPARLRALESA VGESEPAAAAAMALALAGEPAPPAP APPEDHPDEEMGFTIDIKSFLKPGE KTYTQRCRLFVGNLPTDITEEDFKR LFERYGEPSEVFINRDRGFGFIRLE SRTLAEIAKAELDGTILKSRPLRIR FATHGAALTVKNLSPVVSNELLEQA FSQFGPVEKAVVVVDDRGRATGKGF VEFAAKPPARKALERCGDGAFLLTT TPRPVIVEPMEQFDDEDGLPEKLMQ KTQQYHKEREQPPRFAQPGTFEFEY ASRWKALDEMEKQQREQVDRNIREA KEKLEAEMEAARHEHQLMLMRQDLM RRQEELRRLEELRNQELQKRKQIQL RHEEEHRRREEEMIRHREQEELRRQ QEGFKPNYMENREQEMRMGDMGPRG AINMGDAFSPAPAGNQGPPPMMGMN MNNRATIPGPPMGPGPAMGPEGAAN MGTPMMPDNGAVHNDRFPQGPPSQM GSPMGSRTGSETPQAPMSGVGPVSG GPGGFGRGSQGGNFEGPNKRRRYTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
