| Description : |
This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
47.6 kDa |
| AA Sequence : |
MMPQLQFKDAFWCRDFTAHTGYEVL LQRLLDGRKMCKDMEELLRQRAQAE ERYGKELVQIARKAGGQTEINSLRA SFDSLKQQMENVGSSHIQLALTLRE ELRSLEEFRERQKEQRKKYEAVMDR VQKSKLSLYKKAMESKKTYEQKCRD ADDAEQAFERISANGHQKQVEKSQN KARQCKDSATEAERVYRQSIAQLEK VRAEWEQEHRTTCEAFQLQEFDRLT ILRNALWVHSNQLSMQCVKDDELYE EVRLTLEGCSIDADIDSFIQAKSTG TEPPAPVPYQNYYDREVTPLTSSPG IQPSCGMIKRFSGLLHGSPKTTSLA ASAASTETLTPTPERNEGVYTAIAV QEIQGNPASPAQEYRALYDYTAQNP DELDLSAGDILEVILEGEDGWWTVE RNGQRGFVPGSYLEKLTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
