Recombinant Human PTGDS Protein, His-tagged

• Cat.No.: PTGDS-316H
• Product Overview: Recombinant Human PTGDS fused with His tag at C-terminal was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Supplied as a 0.2 µM filtered solution of 20mM TrisHCl, 150mM NaCl, 10%Glycerol, pH7.5
• Molecular Mass: 19.7kD
• Identity: Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
• AA Sequence: APEAQVSVQPNFQQDKFLGRWFSAG LASNSSWLREKKAALSMCKSVVAPA TDGGLNLTSTFLRKNQCETRTMLLQ PAGSLGSYSYRSPHWGSTYSVSVVE TDYDQYALLYSQGSKGPGEDFRMAT LYSRTQTPRAELKEKFTAFCKAQGF TEDTIVFLPQTDKCMTEQVDHHHHH H
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining

Gene Information

• Gene Name: PTGDS prostaglandin D2 synthase 21kDa (brain) [ Homo sapiens ]
• Official Symbol: PTGDS
• Synonyms: PTGDS; prostaglandin D2 synthase 21kDa (brain); prostaglandin D2 synthase (21kD, brain); prostaglandin-H2 D-isomerase; L PGDS; lipocalin type prostaglandin D synthase; PGDS; cerebrin-28; PGD2 synthase; beta-trace protein; prostaglandin D synthase; prostaglandin-D2 synthase; glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin D synthase; lipocalin-type prostaglandin-D synthase; PDS; PGD2; LPGDS; PGDS2; L-PGDS
• Gene ID: 5730
• mRNA Refseq: NM_000954
• Protein Refseq: NP_000945
• MIM: 176803
• UniProt ID: P41222