Recombinant Human PTPRF, Catalytic Domain
Cat.No. : | PTPRF-714H |
Product Overview : | Recombinant human PTPRF was expressed inE.Coli. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PTPRF-714H |
Description : | PTPRF or LAR is a member of the protein tyrosine phosphatase family with an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. PTPRF has been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. |
Source : | E.Coli. |
Biochem/Physiol Actions : | LAR, a leukocyte antigen related protein, is a transmembrane receptor-like protein tyrosine phosphatase (PTPase). Its cytoplasmic domain comprises two tandem domains possessing PTPase homology. Only one domain, LAR-D1, has phosphatase activity. |
Analysis Note : | LAR-D1 catalytic domain comprises amino acids 1275-1613. |
Physical Form : | Solution containing 10 mM imidazole, pH 7.0, 2 mM EDTA, 5 mM DTT, 0.1 M NaCl, and 50% glycerol. |
Assay : | ≥95% (SDS-PAGE). |
Form : | Buffered aqueous glycerol solution. |
Storage Temp : | −70°C. |
Gene Name : | PTPRF protein tyrosine phosphatase, receptor type, F [ Homo sapiens ] |
Synonyms : | PTPRF; protein tyrosine phosphatase, receptor type, F; LCA-homolog; OTTHUMP00000008683; OTTHUMP00000008684; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; LAR; FLJ43335; FLJ45062; FLJ45567; EC 3.1.3.48 |
Gene ID : | 5792 |
mRNA Refseq : | NM_002840 |
Protein Refseq : | NP_002831 |
MIM : | 179590 |
UniProt ID : | P10586 |
Chromosome Location : | 1p34 |
Pathway : | Adherens junction; Cell adhesion molecules (CAMs); Insulin signaling pathway |
Function : | heparan sulfate proteoglycan binding; heparin binding; hydrolase activit; protein binding; protein kinase binding; transmembrane receptor protein tyrosine phosphatase activity |
Products Types
◆ Recombinant Protein | ||
PTPRF-7286M | Recombinant Mouse PTPRF Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPRF-4499R | Recombinant Rat PTPRF Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPRF-463H | Recombinant Human PTPRF Protein, His-tagged | +Inquiry |
PTPRF-4840R | Recombinant Rat PTPRF Protein | +Inquiry |
PTPRF-2062H | Recombinant Human PTPRF, GST-tagged | +Inquiry |
◆ Lysates | ||
PTPRF-1439HCL | Recombinant Human PTPRF cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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