| Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
122.2 kDa |
| AA Sequence : |
MAGAGGGLGVWGNLVLLGLCSWTGA RAPAPNPGRNLTVETQTTSSISLSW EVPDGLDSQNSNYWVQCTGDGGTTE TRNTTATNVTVDGLGPGSLYTCSVW VEKDGVNSSVGTVTTATAPNPVRNL RVEAQTNSSIALTWEVPDGPDPQNS TYGVEYTGDGGRAGTRSTAHTNITV DGLEPGCLYAFSMWVGKNGINSSRE TRNATTAHNPVRNLRVEAQTTSSIS LSWEVPDGTDPQNSTYCVQCTGDGG RTETRNTTDTRVTVDGLGPGSLYTC SVWVEKDGVNSSVEIVTSATAPNPV RNLTVEAQTNSSIALTWEVPDGPDP QNSTYGVEYTGDGGRAGTRSTAYTN ITVDRLEPGCLYVFSVWVGKNGINS SRETRNATTAPNPVRNLHMETQTNS SIALCWEVPDGPYPQDYTYWVEYTG DGGGTETRNTTNTSVTAERLEPGTL YTFSVWAEKNGARGSRQNVSISTVP NAVTSLSKQDWTNSTIALRWTAPQG PGQSSYSYWVSWVREGMTDPRTQST SGTDITLKELEAGSLYHLTVWAERN EVRGYNSTLTAATAPNEVTDLQNET QTKNSVMLWWKAPGDPHSQLYVYWV QWASKGHPRRGQDPQANWVNQTSRT NETWYKVEALEPGTLYNFTVWAERN DVASSTQSLCASTYPDTVTITSCVS TSAGYGVNLIWSCPQGGYEAFELEV GGQRGSQDRSSCGEAVSVLGLGPAR SYPATITTIWDGMKVVSHSVVCHTE SAGVIAGAFVGILLFLILVGLLIFF LKRRNKKKQQKPELRDLVFSSPGDI PAEDFADHVRKNERDSNCGFADEYQ QLSLVGHSQSQMVASASENNAKNRY RNVLPYDWSRVPLKPIHEEPGSDYI NASFMPGLWSPQEFIATQGPLPQTV GDFWRLVWEQQSHTLVMLTNCMEAG RVKCEHYWPLDSQPCTHGHLRVTLV GEEVMENWTVRELLLLQVEEQKTLS VRQFHYQAWPDHGVPSSPDTLLAFW RMLRQWLDQTMEGGPPIVHCSAGVG RTGTLIALDVLLRQLQSEGLLGPFS FVRKMRESRPLMVQTEAQYVFLHQC ILRFLQQSAQAPAEKEVPYEDVENL IYENVAAIQAHKLEVTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
