Recombinant Human PTPRJ
Cat.No. : | PTPRJ-28068TH |
Product Overview : | Recombinant fragment, corresponding to C terminal amino acids 1024-1306 of Human DEP1 containing the catalytic domain and an N terminal properitary Tag. M.Wt 59 kDa. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : | E. coli |
Tissue specificity : | Expressed in the promyelocytic cell line HL60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the interleukin-3 and erythropoietin-dependent leukemic cell line F-36E. |
Biological activity : | 114 U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphateper minute at pH 7.4 and 30C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3mM DTT, 100 mM NaCl, 50 mM Pnpp, and 0.5 ug/ml enzyme. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 2mM EDTA, 10mM Glutathione, 1mM DTT, pH 8.0 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.Contains 9 fibronectin type-III domains.Contains 1 tyrosine-protein phosphatase domain. |
Gene Name : | PTPRJ protein tyrosine phosphatase, receptor type, J [ Homo sapiens ] |
Official Symbol : | PTPRJ |
Synonyms : | PTPRJ; protein tyrosine phosphatase, receptor type, J; receptor-type tyrosine-protein phosphatase eta; CD148; DEP1; HPTPeta; |
Gene ID : | 5795 |
mRNA Refseq : | NM_001098503 |
Protein Refseq : | NP_001091973 |
MIM : | 600925 |
Uniprot ID : | Q12913 |
Chromosome Location : | 11p11.2 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; PDGFR-beta signaling pathway, organism-specific biosystem; Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem; T Cell Receptor Signaling Pathway, organism-specific biosystem; |
Function : | beta-catenin binding; delta-catenin binding; gamma-catenin binding; hydrolase activity; mitogen-activated protein kinase binding; |
Products Types
◆ Recombinant Protein | ||
Ptprj-5247M | Recombinant Mouse Ptprj Protein, Myc/DDK-tagged | +Inquiry |
PTPRJ-2836H | Recombinant Human PTPRJ protein(121-360 aa), C-His-tagged | +Inquiry |
PTPRJ-2837H | Recombinant Human PTPRJ protein(1001-1330 aa), C-His-tagged | +Inquiry |
PTPRJ-2248H | Recombinant Human PTPRJ Protein, Myc/DDK-tagged | +Inquiry |
PTPRJ-2839H | Recombinant Human PTPRJ protein(41-460 aa), C-His-tagged | +Inquiry |
◆ Lysates | ||
PTPRJ-2675HCL | Recombinant Human PTPRJ 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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