Recombinant Human PTPRJ Protein, Myc/DDK-tagged

• Cat.No.: PTPRJ-2248H
• Product Overview: Recombinant protein of human protein tyrosine phosphatase, receptor type, J (PTPRJ), transcript variant 1 with a C-Myc/DDK tag was expressed in HEK293T.

Specification

• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293T
• Species: Human
• Tag: C-Myc/DDK
• Molecular Mass: 142 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: PTPRJ protein tyrosine phosphatase receptor type J [ Homo sapiens (human) ]
• Official Symbol: PTPRJ
• Synonyms: PTPRJ; protein tyrosine phosphatase receptor type J; DEP1; SCC1; CD148; HPTPeta; R-PTP-ETA; receptor-type tyrosine-protein phosphatase eta; CD148 antigen; DEP-1; HPTP eta; R-PTP-J; density-enhanced phosphatase 1; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type, J polypeptide; protein-tyrosine phosphatase eta; susceptibility to colon cancer 1, mouse, homolog of; EC 3.1.3.48
• Gene ID: 5795
• mRNA Refseq: NM_002843
• Protein Refseq: NP_002834
• MIM: 600925
• UniProt ID: Q12913