Recombinant Human QPRT Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: QPRT-6694H
• Product Overview: QPRT MS Standard C13 and N15-labeled recombinant protein (NP_055113) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 30.8 kDa
• AA Sequence: MDAEGLALLLPPVTLAALVDSWLRE DCPGLNYAALVSGAGPSQAALWAKS PGILAGQPFFDAIFTQLNCQVSWFL PEGSKLVPVARVAEVRGPAHCLLLG ERVALNTLARCSGIASAAAAAVEAA RGAGWTGHVAGTRKTTPGFRLVEKY GLLVGGAASHRYDLGGLVMVKDNHV VAAGGVEKAVRAARQAADFALKVEV ECSSLQEAVQAAEAGADLVLLDNFK PEELHPTATVLKAQFPSVAVEASGG ITLDNLPQFCGPHIDVISMGMLTQA APALDFSLKLFAKEVAPVPKIHTRT RPLEQKLISEEDLAANDILDYKDDD DKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: QPRT quinolinate phosphoribosyltransferase [ Homo sapiens (human) ]
• Official Symbol: QPRT
• Synonyms: QPRT; quinolinate phosphoribosyltransferase; nicotinate-nucleotide pyrophosphorylase [carboxylating]; nicotinate nucleotide pyrophosphorylase (carboxylating); QPRTase; QAPRTase; nicotinate-nucleotide pyrophosphorylase (carboxylating)
• Gene ID: 23475
• mRNA Refseq: NM_014298
• Protein Refseq: NP_055113
• MIM: 606248
• UniProt ID: Q15274