| Description : |
This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
95.7 kDa |
| AA Sequence : |
MAVEDEGLRVFQSVKIKIGEAKNLP SYPGPSKMRDCYCTVNLDQEEVFRT KIVEKSLCPFYGEDFYCEIPRSFRH LSFYIFDRDVFRRDSIIGKVAIQKE DLQKYHNRDTWFQLQHVDADSEVQG KVHLELRLSEVITDTGVVCHKLATR IVECQGLPIVNGQCDPYATVTLAGP FRSEAKKTKVKRKTNNPQFDEVFYF EVTRPCSYSKKSHFDFEEEDVDKLE IRVDLWNASNLKFGDEFLGELRIPL KVLRQSSSYEAWYFLQPRDNGSKSL KPDDLGSLRLNVVYTEDHVFSSDYY SPLRDLLLKSADVEPVSASAAHILG EVCREKQEAAVPLVRLFLHYGRVVP FISAIASAEVKRTQDPNTIFRGNSL ASKCIDETMKLAGMHYLHVTLKPAI EEICQSHKPCEIDPVKLKDGENLEN NMENLRQYVDRVFHAITESGVSCPT VMCDIFFSLREAAAKRFQDDPDVRY TAVSSFIFLRFFAPAILSPNLFQLT PHHTDPQTSRTLTLISKTVQTLGSL SKSKSASFKESYMATFYEFFNEQKY ADAVKNFLDLISSSGRRDPKSVEQP IVLKEGFMIKRAQGRKRFGMKNFKK RWFRLTNHEFTYHKSKGDQPLYSIP IENILAVEKLEEESFKMKNMFQVIQ PERALYIQANNCVEAKDWIDILTKV SQCNQKRLTVYHPSAYLSGHWLCCR APSDSAPGCSPCTGGLPANIQLDID GDRETERIYSLFNLYMSKLEKMQEA CGSKSVYDGPEQEEYSTFVIDDPQE TYKTLKQVIAGVGALEQEHAQYKRD KFKKTKYGSQEHPIGDKSFQNYIRQ QSETSTHSITRTRPLEQKLISEEDL AANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
