| Description : |
This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
92 kDa |
| AA Sequence : |
MGSDKRVSRTERSGRYGSIIDRDDR DERESRSRRRDSDYKRSSDDRRGDR YDDYRDYDSPERERERRNSDRSEDG YHSDGDYGEHDYRHDISDERESKTI MLRGLPITITESDIREMMESFEGPQ PADVRLMKRKTGVSRGFAFVEFYHL QDATSWMEANQKKLVIQGKHIAMHY SNPRPKFEDWLCNKCCLNNFRKRLK CFRCGADKFDSEQEVPPGTTESVQS VDYYCDTIILRNIAPHTVVDSIMTA LSPYASLAVNNIRLIKDKQTQQNRG FAFVQLSSAMDASQLLQILQSLHPP LKIDGKTIGVDFAKSARKDLVLSDG NRVSAFSVASTAIAAAQWSSTQSQS GEGGSVDYSYLQPGQDGYAQYAQYS QDYQQFYQQQAGGLESDASSASGTA VTTTSAAVVSQSPQLYNQTSNPPGS PTEEAQPSTSTSTQAPAASPTGVVP GTKYAVPDTSTYQYDESSGYYYDPT TGLYYDPNSQYYYNSLTQQYLYWDG EKETYVPAAESSSHQQSGLPPAKEG KEKKEKPKSKTAQQIAKDMERWAKS LNKQKENFKNSFQPVNSLREEERRE SAAADAGFALFEKKGALAERQQLIP ELVRNGDEENPLKRGLVAAYSGDSD NEEELVERLESEEEKLADWKKMACL LCRRQFPNKDALVRHQQLSDLHKQN MDIYRRSRLSEQELEALELREREMK YRDRAAERREKYGIPEPPEPKRKKQ FDAGTVNYEQPTKDGIDHSNIGNKM LQAMGWREGSGLGRKCQGITAPIEA QVRLKGAGLGAKGSAYGLSGADSYK DAVRKAMFARFTEMESGPTRTRRLE QKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
