Active Recombinant Human RFFL Protein, GST-tagged
Cat.No. : | RFFL-639H |
Product Overview : | Recombinant Human RFFL fused with GST tag at N-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | E3 ubiquitin-protein ligase RNF34L, also named CARP2 (Caspases-8/10 Associated RING protein 2), acts as RING‑domain E3 ligases, ubiquitinates apical caspases and targets them for proteasome-mediated degradation. CARP gene silencing inhibits tumor cell survival and increases cancer cell sensitivity to the death ligand or chemotherapy-induced apoptosis. CARP proteins target the tumor suppressor p53 for degradation. RNF34L also acts at the level of endocytic vesicles to limit the intensity of TNF-induced NF-κB activation by the regulated elimination of the adaptor protein RIP1. |
Source : | Insect cells |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol |
Bio-activity : | 18 nmol/min/mg |
Molecular Mass : | 73 kDa |
Purity : | >70% |
Applications : | Ubiquitin Enzyme Assay, Western Blot |
Stability : | 1 year at - 70 centigrade from the date of shipment. |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 ug/ml |
Gene Name : | RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase [ Homo sapiens ] |
Official Symbol : | RFFL |
Synonyms : | RFFL; ring finger and FYVE-like domain containing E3 ubiquitin protein ligase; ring finger and FYVE like domain containing; E3 ubiquitin-protein ligase rififylin; fring; rififylin; RNF34L; RNF189; RING finger protein 189; caspase regulator CARP2; FYVE-RING finger protein SAKURA; ring finger and FYVE-like domain containing 1; caspases-8 and -10-associated RING finger protein 2; RING finger and FYVE-like domain-containing protein 1; CARP2; FRING; CARP-2; RIFIFYLIN; |
Gene ID : | 117584 |
mRNA Refseq : | NM_001017368 |
Protein Refseq : | NP_001017368 |
MIM : | 609735 |
UniProt ID : | Q8WZ73 |
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◆ Lysates | ||
RFFL-538HCL | Recombinant Human RFFL lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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