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Active Recombinant Human RFFL Protein, GST-tagged

Cat.No. : RFFL-639H
Product Overview : Recombinant Human RFFL fused with GST tag at N-terminal was expressed in Insect cells.
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  • Gene Information
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Description : E3 ubiquitin-protein ligase RNF34L, also named CARP2 (Caspases-8/10 Associated RING protein 2), acts as RING‑domain E3 ligases, ubiquitinates apical caspases and targets them for proteasome-mediated degradation. CARP gene silencing inhibits tumor cell survival and increases cancer cell sensitivity to the death ligand or chemotherapy-induced apoptosis. CARP proteins target the tumor suppressor p53 for degradation. RNF34L also acts at the level of endocytic vesicles to limit the intensity of TNF-induced NF-κB activation by the regulated elimination of the adaptor protein RIP1.
Source : Insect cells
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol
Bio-activity : 18 nmol/min/mg
Molecular Mass : 73 kDa
Purity : >70%
Applications : Ubiquitin Enzyme Assay, Western Blot
Stability : 1 year at - 70 centigrade from the date of shipment.
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ml
Gene Name : RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase [ Homo sapiens ]
Official Symbol : RFFL
Synonyms : RFFL; ring finger and FYVE-like domain containing E3 ubiquitin protein ligase; ring finger and FYVE like domain containing; E3 ubiquitin-protein ligase rififylin; fring; rififylin; RNF34L; RNF189; RING finger protein 189; caspase regulator CARP2; FYVE-RING finger protein SAKURA; ring finger and FYVE-like domain containing 1; caspases-8 and -10-associated RING finger protein 2; RING finger and FYVE-like domain-containing protein 1; CARP2; FRING; CARP-2; RIFIFYLIN;
Gene ID : 117584
mRNA Refseq : NM_001017368
Protein Refseq : NP_001017368
MIM : 609735
UniProt ID : Q8WZ73

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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