Recombinant Human RGS1, His-tagged

• Cat.No.: RGS1-30015TH
• Product Overview: Recombinant fragment, corresponding to amino acids 14-209 of Human RGS1 with N-terminal His tag; MWt 26 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 14-209 a.a.
• Description: This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
• Conjugation: HIS
• Tissue specificity: B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high.
• Form: Liquid
• Storage buffer: Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 2mM DTT, 0.1mM PMSF, pH 7.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 1 RGS domain.

Gene Information

• Gene Name: RGS1 regulator of G-protein signaling 1 [ Homo sapiens ]
• Official Symbol: RGS1
• Synonyms: RGS1; regulator of G-protein signaling 1; IER1, regulator of G protein signalling 1; 1R20; BL34; IR20
• Gene ID: 5996
• mRNA Refseq: NM_002922
• Protein Refseq: NP_002913
• MIM: 600323
• Uniprot ID: Q08116
• Chromosome Location: 1q31
• Pathway: CXCR4-mediated signaling events, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
• Function: GTPase activator activity; calmodulin binding; signal transducer activity