Recombinant Human RNF213 Protein, MYC/DDK-tagged

• Cat.No.: RNF213-675H
• Product Overview: Recombinant Human RNF213 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 118.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: RNF213 ring finger protein 213 [ Homo sapiens ]
• Official Symbol: RNF213
• Synonyms: RNF213; ring finger protein 213; C17orf27, chromosome 17 open reading frame 27 , KIAA1618 , moyamoya disease 2 , Moyamoya disease 2 , MYMY2; RING finger protein 213; KIAA1554; NET57; mysterin; ALK lymphoma oligomerization partner on chromosome 17; ALO17; MYMY2; MYSTR; C17orf27; KIAA1618; MGC9929; FLJ13051; MGC46622; DKFZp762N1115
• Gene ID: 57674
• mRNA Refseq: NM_020954
• Protein Refseq: NP_066005
• MIM: 613768
• UniProt ID: Q63HN8