"RNF34" Related Products


Recombinant Human RNF34 Protein, GST-tagged, Active

Cat.No. : RNF34-638H
Product Overview : Recombinant Human RNF34 fused with GST tag at N-terminal was expressed in Insect cells.
Description : E3 ubiquitin-protein ligase RNF34, also named CARP1 (Caspases-8/10 Associated RING protein 1), acts as RING‑domain E3 ligases, ubiquitinates apical caspases and targets them for proteasome-mediated degradation. CARP gene silencing inhibits tumor cell survival and increases cancer cell sensitivity to the death ligand or chemotherapy-induced apoptosis. CARP proteins target the tumor suppressor p53 for degradation. RNF34 is also a negative regulator of the NOD1 pathway through direct interaction and ubiquitination of NOD1.
Source : Insect cells
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol
Bio-activity : 21 nmol/min/mg
Molecular Mass : 68 kDa
Purity : >80%
Applications : Ubiquitin Enzyme Assay, Western Blot
Stability : 1 year at - 70 centigrade from the date of shipment.
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ml
Gene Name : RNF34 ring finger protein 34, E3 ubiquitin protein ligase [ Homo sapiens ]
Official Symbol : RNF34
Synonyms : RNF34; ring finger protein 34, E3 ubiquitin protein ligase; ring finger protein 34; E3 ubiquitin-protein ligase RNF34; FLJ21786; RIF; RIFF; caspase regulator CARP1; RING finger protein RIFF; FYVE-RING finger protein MOMO; caspases-8 and -10-associated RING finger protein 1; human RING finger homologous to inhibitor of apoptosis protein; RFI; hRFI; CARP1; CARP-1;
Gene ID : 80196
mRNA Refseq : NM_025126
Protein Refseq : NP_079402
MIM : 608299
UniProt ID : Q969K3

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