| Description : |
Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphosphate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
42.2 kDa |
| AA Sequence : |
MWVLTPAAFAGKLLSVFRQPLSSLW RSLVPLFCWLRATFWLRATKRRKQQ LVLRGPDETKEEEEDPPLPTTPTSV NYHFTRQCNYKCGFCFHTAKTSFVL PLEEAKRGLLLLKEAGMEKINFSGG EPFLQDRGEYLGKLVRFCKVELRLP SVSIVSNGSLIRERWFQNYGEYLDI LAISCDSFDEEVNVLIGRGQGKKNH VENLQKLRRWCRDYRVAFKINSVIN RFNVEEDMTEQIKALNPVRWKVFQC LLIEGENCGEDALREAERFVIGDEE FERFLERHKEVSCLVPESNQKMKDS YLILDEYMRFLNCRKGRKDPSKSIL DVGVEEAIKFSGFDEKMFLKRGGKY IWSKADLKLDWTRTRPLEQKLISEE DLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
