Recombinant Human RTN4R protein, His-tagged

• Cat.No.: RTN4R-30H
• Product Overview: Recombinant human RTN4R, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Specification

• Description: RTN4R, also known as reticulon-4 receptor, is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. It is expressed predominantly in neurons and their axons in the central nervous systems (CNS). It may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). It may play a role in regulating the function of the gap junctions.
• Source: Insect cells
• Species: Human
• Tag: His
• Form: Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
• Molecular Mass: 46.3kDa (429aa)
  40-57kDa (SDS-PAGE under reducing conditions)
• AA Sequence: CPGACVCYNE PKVTTSCPQQ GLQAVPVGIP AASQRIFLHG NRISHVPAAS FRACRNLTIL WLHSNVLARI DAAAFTGLAL LEQLDLSDNAQLRSVDPATF HGLGRLHTLH LDRCGLQELG PGLFRGLAAL QYLYLQDNAL QALPDDTFRD LGNLTHLFLH GNRISSVPER AFRGLHSLDRLLLHQNRVAH VHPHAFRDLG RLMTLYLFAN NLSALPTEAL APLRALQYLR LNDNPWVCDC RARPLWAWLQ KFRGSSSEVP CSLPQRLAGRDLKRLAANDL QGCAVATGPY HPIWTGRATD EEPLGLPKCC QPDAADKASV LEPGRPASAG NALKGRVPPG DSPPGNGSGP RHINDSPFGT
  LPGSAEPPLT AVRPEGSEPP GFPTSGPRRR PGCSRKNRTR SHCRLGQAGS GGGGTGDSEG SLEHHHHHH
• Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Purity: > 90% by SDS - PAGE
• Storage: Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20centigrade or -70centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by Absorbance at 280nm)

Gene Information

• Gene Name: RTN4R reticulon 4 receptor [ Homo sapiens ]
• Official Symbol: RTN4R
• Synonyms: RTN4R; reticulon 4 receptor; reticulon-4 receptor; NOGOR; UNQ330/PRO526; nogo receptor; Nogo-66 receptor; NGR
• Gene ID: 65078
• mRNA Refseq: NM_023004
• Protein Refseq: NP_075380
• MIM: 605566
• UniProt ID: Q9BZR6
• Chromosome Location: 22q11
• Pathway: p75(NTR)-mediated signaling, organism-specific biosystem
• Function: protein binding; receptor activity