| Description : |
This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame, downstream translation termination codon via a stop codon readthrough mechanism. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
66.8 kDa |
| AA Sequence : |
MATAAYEQLKLHITPEKFYVEACDD GADDVLTIDRVSTEVTLAVKKDVPP SAVTRPIFGILGTIHLVAGNYLIVI TKKIKVGEFFSHVVWKATDFDVLSY KKTMLHLTDIQLQDNKTFLAMLNHV LNVDGFYFSTTYDLTHTLQRLSNTS PEFQEMSLLERADQRFVWNGHLLRE LSAQPEVHRFALPVLHGFITMHSCS INGKYFDWILISRRSCFRAGVRYYV RGIDSEGHAANFVETEQIVHYNGSK ASFVQTRGSIPVFWSQRPNLKYKPL PQISKVANHMDGFQRHFDSQVIIYG KQVIINLINQKGSEKPLEQTFATMV SSLGSGMMRYIAFDFHKECKNMRWD RLSILLDQVAEMQDELSYFLVDSAG QVVANQEGVFRSNCMDCLDRTNVIQ SLLARRSLQAQLQRLGVLHVGQKLE EQDEFEKIFKNAWADNANACAKQYA GTGALKTDFTRTGKRTHLGLIMDGW NSMIRYYKNNFSDGFRQDSIDLFLG NYSVDELESHSPLSVPRDWKFLALP IIMVVAFSMCIICLLMAGDTWTETL AYVLFWGVASIGTFFIILYNGKDFV DAPRLVQKEKIDTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
