Recombinant Human SARS2 Protein, His-tagged

• Cat.No.: SARS2-2673H
• Product Overview: Recombinant Human SARS2 Protein (Leu242-Ser518) with a N-His tag was expressed in E. coli.

Specification

• Description: This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene.
• Source: E. coli
• Species: Human
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 34.4 kDa
  Accurate Molecular Mass: 34 kDa
• Protein length: Leu242-Ser518
• Endotoxin: <1.0 EU per 1µg (determined by the LAL method).
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: SARS2 seryl-tRNA synthetase 2, mitochondrial [ Homo sapiens (human) ]
• Official Symbol: SARS2
• Synonyms: SARS2; seryl-tRNA synthetase 2, mitochondrial; SARSM, serine tRNA ligase, mitochondrial, seryl tRNA synthetase 2; serine--tRNA ligase, mitochondrial; FLJ20450; mtSerRS; SARS; serine tRNA ligase 2; mitochondrial; SerRSmt; SERS; SYS; seryl-tRNA(Ser/Sec) synthetase; serine-tRNA ligase, mitochondrial; mitochondrial seryl-tRNA synthetase; serine tRNA ligase 2, mitochondrial; seryl-tRNA synthetase, mitochondrial; SARSM; SerRS
• Gene ID: 54938
• mRNA Refseq: NM_001145901
• Protein Refseq: NP_001139373
• MIM: 612804
• UniProt ID: Q9NP81