Recombinant Human SCARB1 Protein (33-443 aa), His-SUMO-tagged

• Cat.No.: SCARB1-1087H
• Product Overview: Recombinant Human SCARB1 Protein (33-443 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Cancer. Protein Description: Partial.

Specification

• Description: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma mbrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and Extracellular domain donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.
• Source: E. coli
• Species: Human
• Tag: His-SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 62.7 kDa
• Protein length: 33-443 aa
• AA Sequence: PSLIKQQVLKNVRIDPSSLSFNMWK EIPIPFYLSVYFFDVMNPSEILKGE KPQVRERGPYVYREFRHKSNITFNN NDTVSFLEYRTFQFQPSKSHGSESD YIVMPNILVLGAAVMMENKPMTLKL IMTLAFTTLGERAFMNRTVGEIMWG YKDPLVNLINKYFPGMFPFKDKFGL FAELNNSDSGLFTVFTGVQNISRIH LVDKWNGLSKVDFWHSDQCNMINGT SGQMWPPFMTPESSLEFYSPEACRS MKLMYKESGVFEGIPTYRFVAPKTL FANGSIYPPNEGFCPCLESGIQNVS TCRFSAPLFLSHPHFLNADPVLAEA VTGLHPNQEAHSLFLDIHPVTGIPM NCSVKLQLSLYMKSVAGIGQTGKIE PVVLPLLWFAESGAMEGETLHTFYT QLVLMPKVMHY
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: SCARB1 scavenger receptor class B, member 1 [ Homo sapiens ]
• Official Symbol: SCARB1
• Synonyms: SCARB1; CLA 1; CLA1; SR BI; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6; MGC138242
• Gene ID: 949
• mRNA Refseq: NM_001082959
• Protein Refseq: NP_001076428
• MIM: 601040
• UniProt ID: Q8WTV0