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Recombinant Human SCNN1A protein, His & T7-tagged

Cat.No. : SCNN1A-7976H
Product Overview : Recombinant Human SCNN1A aa. (Tyr112~Thr543 (Accession # P37088)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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  • Gene Information
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Description : Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 53.5kDa
Protein length : Tyr112~Thr543 (Accession # P37088)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >90%
Characteristic : The isoelectric point is 8.1.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage Buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : SCNN1A sodium channel epithelial 1 alpha subunit [ Homo sapiens (human) ]
Official Symbol : SCNN1A
Synonyms : SCNN1A; sodium channel epithelial 1 alpha subunit; BESC2; ENaCa; SCNEA; SCNN1; ENaCalpha; amiloride-sensitive sodium channel subunit alpha; alpha ENaC-2; alpha-ENaC; alpha-NaCH; amiloride-sensitive epithelial sodium channel alpha subunit; amiloride-sensitive sodium channel subunit alpha 2; epithelial Na(+) channel subunit alpha; nasal epithelial sodium channel alpha subunit; nonvoltage-gated sodium channel 1 subunit alpha; sodium channel, non voltage gated 1 alpha subunit; sodium channel, non-voltage-gated 1 alpha; sodium channel, nonvoltage-gated 1 alpha
Gene ID : 6337
mRNA Refseq : NM_001038.5
Protein Refseq : NP_001029.1
UniProt ID : P37088

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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