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Recombinant Human SEMA4D Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : SEMA4D-2696H
Product Overview : SEMA4D MS Standard C13 and N15-labeled recombinant protein (NP_006369) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 96.2 kDa
AA Sequence : MRMCTPIRGLLMALAVMFGTAMAFA PIPRITWEHREVHLVQFHEPDIYNY SALLLSEDKDTLYIGAREAVFAVNA LNISEKQHEVYWKVSEDKKAKCAEK GKSKQTECLNYIRVLQPLSATSLYV CGTNAFQPACDHLNLTSFKFLGKNE DGKGRCPFDPAHSYTSVMVDGELYS GTSYNFLGSEPIISRNSSHSPLRTE YAIPWLNEPSFVFADVIRKSPDSPD GEDDRVYFFFTEVSVEYEFVFRVLI PRIARVCKGDQGGLRTLQKKWTSFL KARLICSRPDSGLVFNVLRDVFVLR SPGLKVPVFYALFTPQLNNVGLSAV CAYNLSTAEEVFSHGKYMQSTTVEQ SHTKWVRYNGPVPKPRPGACIDSEA RAANYTSSLNLPDKTLQFVKDHPLM DDSVTPIDNRPRLIKKDVNYTQIVV DRTQALDGTVYDVMFVSTDRGALHK AISLEHAVHIIEETQLFQDFEPVQT LLLSSKKGNRFVYAGSNSGVVQAPL AFCGKHGTCEDCVLARDPYCAWSPP TATCVALHQTESPSRGLIQEMSGDA SVCPDKSKGSYRQHFFKHGGTAELK CSQKSNLARVFWKFQNDVLKAESPK YGLMGRKNLLIFNLSEGDSGVYQCL SEERVKNKTVFQVVAKHVLEVKVVP KPVVAPTLSVVQTEGSRIATKVLVA STQGSSPPTPAVQATSSGAITLPPK PAPTGTSCEPKIVINTVPQLHSEKT MYLKSSDNRLLMSLFLFFFVLFLCL FFYNCYKGYLPRQCLKFRSALLIGK KKPKSDFCDREQSLKETLVEPGSFS QQNGEHPKPALDTGYETEQDTITSK VPTDREDSQRIDDLSARDKPFDVKC ELKFADSDADGDTRTRPLEQKLISE EDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : SEMA4D semaphorin 4D [ Homo sapiens (human) ]
Official Symbol : SEMA4D
Synonyms : SEMA4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; C9orf164, chromosome 9 open reading frame 164, SEMAJ; semaphorin-4D; CD100; coll 4; FLJ39737; M sema G; A8; GR3; BB18; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D; SEMAJ; coll-4; C9orf164; M-sema-G; FLJ33485; FLJ34282; FLJ46484; MGC169138; MGC169141;
Gene ID : 10507
mRNA Refseq : NM_006378
Protein Refseq : NP_006369
MIM : 601866
UniProt ID : Q92854

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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