| Description : |
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
His-GST |
| Molecular Mass : |
71.7 kDa |
| Protein length : |
1-369 |
| Purity : |
>95% confirmed by 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-6xHis (WB). |
| Applications : |
ELISA, Western Blot, Antibody Production, Protein array |
| Quality Control Test : |
10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-GST monoclonal and peptide fingerprinting by MALDI-TOF mass spectrometry. |
| Storage : |
Store working aliquots at 4 centigrade for up to one week. For extended storage, conserve at −80 centigrade. |
| Expiry : |
12 months from the date of purchase, if it is properly stored. |
| Storage Buffer : |
Phosphate-Buffered Saline (PBS), pH 7.4. No preservatives added. |
| Shipping : |
Dry Ice |
