Active Recombinant Human SERPINB3 Protein, His-tagged
Cat.No. : | SERPINB3-506H |
Product Overview : | Recombinant Human SERPINB3 (Asn2-Pro390) protein with an N-terminal Met and 6-His tag was expressed in Sf 21. |
- Specification
- Gene Information
- Related Products
Description : | Serpin B3, also known as squamous cell carcinoma antigen-1 (SCCA-1), is a member of the serpin superfamily of serine protease inhibitors (1). Serpins primarily inhibit serine proteases and some are known to inhibit caspases and papain-like cysteine proteases (1). Serpin B3 belongs to the subgroup ovalbumin-related serpins which are involved in the regulation of apoptosis, inflammation, angiogenesis and embryogenesis (2). Serpin B3 was initially isolated from human cervical squamous cell tissue. It is a tumor marker for squamous cell carcinomas in various areas including the cervix, head, neck and lung (3). Unlike typical serpins, Serpin B3 shows inhibitory activity against papain-like lysosomal cysteine proteases Cathepsin K, L, and S, while lacking inhibitory activity against serine proteases (4). |
Source : | Sf 21 |
Species : | Human |
Tag : | His |
Bio-activity : | Measured by its ability to inhibit active Cathepsin L cleavage of a fluorogenic peptide substrate Z-LR-AMC. The IC50 is <5 nM. |
Molecular Mass : | 45 kDa |
N-terminal Sequence Analysis : | Met |
Endotoxin : | <1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 3 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, -20 to -70 centigrade under sterile conditions after opening. |
Storage Buffer : | Supplied as a 0.2 μm filtered solution in Tris, NaCl and Glycerol. |
Gene Name : | SERPINB3 serpin family B member 3 [ Homo sapiens (human) ] |
Official Symbol : | SERPINB3 |
Synonyms : | SERPINB3; serpin family B member 3; HsT1196; Protein T4-A; SCC; SCCA; SCCA1; SCCA1SCCA-1; SCCA-PD; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3; Serpin B3; serpin peptidase inhibitor, clade B (ovalbumin), member 3; Squamous cell carcinoma antigen 1; T4-A; SSCA1; SCCA-1; serpin B3; protein T4-A; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3; serpin peptidase inhibitor, clade B (ovalbumin), member 3; squamous cell carcinoma antigen 1 |
Gene ID : | 6317 |
mRNA Refseq : | NM_006919 |
Protein Refseq : | NP_008850 |
MIM : | 600517 |
UniProt ID : | P29508 |
Products Types
◆ Recombinant Protein | ||
SERPINB3-2876H | Recombinant Human Full length SERPINB3 protein(1-390 aa), N-MBP & C-His-tagged | +Inquiry |
SERPINB3-2685H | Recombinant Human SERPINB3 Protein, His-tagged | +Inquiry |
SERPINB3-2684H | Recombinant Human SERPINB3 Protein, His-tagged | +Inquiry |
SERPINB3-856H | Recombinant Human SERPINB3 Protein, MYC/DDK-tagged | +Inquiry |
SERPINB3-38H | Recombinant Human SERPINB3 Protein, C-6His tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
SERPINB3-460HCL | Recombinant Human SERPINB3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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