"SETMAR" Related Products


Recombinant Human SETMAR protein, His-tagged

Cat.No.: SETMAR-93H
Product Overview: Recombinant Human SETMAR, fused with N-His tag, was expressed in E. coli.
Description: Histone methyltransferase that methylates "Lys-4" and "Lys-36" of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 "Lys-36". Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5"-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA.
Source: E.coli
Species: Human
Tag: His
Form: 20mM Tris.Cl, 50mM NaCl, 50% Glycerol, pH9.0.
Molecular Mass: 42.1kDa(including fusion tag)
Protein length: 358aa(including fusion tag)
Applications: WB, ELISA, IP, antibody production, protein array
Storage: Store at -80centigrade and avoid repeated freeze-thaw cycles
Gene Name: SETMAR SET domain and mariner transposase fusion gene [ Homo sapiens ]
Official Symbol: SETMAR
Synonyms: SETMAR; SET domain and mariner transposase fusion gene; histone-lysine N-methyltransferase SETMAR; metnase; hsMar1; SET domain and mariner transposase fusion gene-containing protein; METNASE;
Gene ID: 6419
mRNA Refseq: NM_001243723
Protein Refseq: NP_001230652
MIM: 609834
UniProt ID: Q53H47
Chromosome Location: 3p26.2
Pathway: Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem;
Function: endonuclease activity; histone-lysine N-methyltransferase activity; hydrolase activity; metal ion binding; methyltransferase activity; protein binding; protein homodimerization activity; structure-specific DNA binding; structure-specific DNA binding; transferase activity; transposase activity; zinc ion binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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