| Species : |
Human |
| Source : |
HEK293 |
| Tag : |
His |
| Protein Length : |
1-402 aa |
| Description : |
Native sex hormone-binding globulin (SHBG) is a homodimeric glycoprotein of approximately 90 kDa, with each monomer comprising 373 amino acids, two intramolecular disulfide bonds, and glycosylation sites including two biantennary N-linked and one O-linked oligosaccharide. Its serum concentration is influenced not only by androgens and estrogens but also by thyroid hormones and various metabolic factors. Abnormal SHBG levels are associated with a range of conditions, including hyper- and hypoandrogenism, thyroid and pituitary disorders, liver disease, and hormone-related cancers such as breast and prostate cancer. |
| Form : |
Liquid in DPBS. |
| Molecular Mass : |
Expected Molecular Weight: 48.23 kDa
Observed Molecular Weight: 50.0 kDa |
| Storage : |
Short Term Storage: -80 centigrade
Long Term Storage: -80 centigrade
Avoid multiple freeze-thaw cycles, Can be frozen, but avoid multiple freeze-thaw cycles. |
| Concentration : |
0.13 mg/mL |
| Reference : |
1. Avvakumov GV, Grishkovskaya I, Muller YA, Hammond GL.(2001) Resolution of the human sex hormone-binding globulin dimer interface and evidence for two steroid-binding sites per homodimer. J Biol Chem.;276(37):34453-7. doi: 10.1074/jbc.M106274200. Epub 2001 Jul 16. PMID: 11457864.
2. Thaler, M.A., Seifert-Klauss, V., & Luppa, P.B. (2015). The biomarker sex hormone-binding globulin – From established applications to emerging trends in clinical medicine. Best Practice & Research Clinical Endocrinology & Metabolism, 29(5), 749–760.
3. Adaway J, Keevil B, Miller A, Monaghan PJ, Merrett N, Owen L. Ramifications of variability in sex hormone-binding globulin measurement by different immunoassays on the calculation of free testosterone. Annals of Clinical Biochemistry. 2019;57(1):88-94. |
