Recombinant Human SGK3 Protein (Q2-L496), GST tagged

• Cat.No.: SGK3-1181H
• Product Overview: Recombinant Human GST-TEV-GG-SGK3(Q2-L496 end) Protein was expressed in Insect cell.

Specification

• Description: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: Liquid
• Protein Length: Q2-L496
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: SGK3 serum/glucocorticoid regulated kinase family, member 3 [ Homo sapiens (human) ]
• Official Symbol: SGK3
• Synonyms: SGK3; serum/glucocorticoid regulated kinase family, member 3; serum/glucocorticoid regulated kinase like, SGK2, SGKL; serine/threonine-protein kinase Sgk3; cytokine-independent survival kinase; CISK; SGK2; SGKL; DKFZp781N0293
• Gene ID: 23678
• mRNA Refseq: NM_001033578
• Protein Refseq: NP_001028750
• MIM: 607591
• UniProt ID: Q96BR1