Recombinant Human SH3BP5 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: SH3BP5-1761H
• Product Overview: SH3BP5 MS Standard C13 and N15-labeled recombinant protein (NP_004835) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 50.4 kDa
• AA Sequence: MDAALKRSRSEEPAEILPPARDEEE EEEEGMEQGLEEEEEVDPRIQGELE KLNQSTDDINRRETELEDARQKFRS VLVEATVKLDELVKKIGKAVEDSKP YWEARRVARQAQLEAQKATQDFQRA TEVLRAAKETISLAEQRLLEDDKRQ FDSAWQEMLNHATQRVMEAEQTKTR SELVHKETAARYNAAMGRMRQLEKK LKRAINKSKPYFELKAKYYVQLEQL KKTVDDLQAKLTLAKGEYKMALKNL EMISDEIHERRRSSAMGPRGCGVGA EGSSTSVEDLPGSKPEPDAISVASE AFEDDSCSNFVSEDDSETQSVSSFS SGPTSPSEMPDQFPAVVRPGSLDLP SPVSLSEFGMMFPVLGPRSECSGAS SPECEVERGDRAEGAENKTSDKANN NRGLSSSSGSGGSSKSQSSTSPEGQ ALENRMKQLSLQCSKGRDGIIADIK MVQIGTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: SH3BP5 SH3 domain binding protein 5 [ Homo sapiens (human) ]
• Official Symbol: SH3BP5
• Synonyms: SH3BP5; SH3-domain binding protein 5 (BTK-associated); SH3 domain-binding protein 5; Sab; SH3 binding protein; SH3BP-5; SH3 domain-binding protein that preferentially associates with BTK; SAB
• Gene ID: 9467
• mRNA Refseq: NM_004844
• Protein Refseq: NP_004835
• MIM: 605612
• UniProt ID: O60239