| Description : |
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
103.7 kDa |
| AA Sequence : |
MVMADGPRHLQRGPVRVGFYDIEGT LGKGNFAVVKLGRHRITKTEVAIKI IDKSQLDAVNLEKIYREVQIMKMLD HPHIIKLYQVMETKSMLYLVTEYAK NGEIFDYLANHGRLNESEARRKFWQ ILSAVDYCHGRKIVHRDLKAENLLL DNNMNIKIADFGFGNFFKSGELLAT WCGSPPYAAPEVFEGQQYEGPQLDI WSMGVVLYVLVCGALPFDGPTLPIL RQRVLEGRFRIPYFMSEDCEHLIRR MLVLDPSKRLTIAQIKEHKWMLIEV PVQRPVLYPQEQENEPSIGEFNEQV LRLMHSLGIDQQKTIESLQNKSYNH FAAIYFLLVERLKSHRSSFPVEQRL DGRQRRPSTIAEQTVAKAQTVGLPV TMHSPNMRLLRSALLPQASNVEAFS FPASGCQAEAAFMEEECVDTPKVNG CLLDPVPPVLVRKGCQSLPSNMMET SIDEGLETEGEAEEDPAHAFEAFQS TRSGQRRHTLSEVTNQLVVMPGAGK IFSMNDSPSLDSVDSEYDMGSVQRD LNFLEDNPSLKDIMLANQPSPRMTS PFISLRPTNPAMQALSSQKREVHNR SPVSFREGRRASDTSLTQGIVAFRQ HLQNLARTKGILELNKVQLLYEQIG PEADPNLAPAAPQLQDLASSCPQEE VSQQQESVSTLPASVHPQLSPRQSL ETQYLQHRLQKPSLLSKAQNTCQLY CKEPPRSLEQQLQEHRLQQKRLFLQ KQSQLQAYFNQMQIAESSYPQPSQQ LPLPRQETPPPSQQAPPFSLTQPLS PVLEPSSEQMQYSPFLSQYQEMQLQ PLPSTSGPRAAPPLPTQLQQQQPPP PPPPPPPRQPGAAPAPLQFSYQTCE LPSAASPAPDYPTPCQYPVDGAQQS DLTGPDCPRSPGLQEAPSSYDPLAL SELPGLFDCEMLDAVDPQHNGYVLV NTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
