Recombinant Human SIRPB1 Protein, His-tagged

• Cat.No.: SIRPB1-001H
• Product Overview: Recombinant human SIRPB1(30-371aa) protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: 30-371 a.a.
• Description: SIRPB1, also known as signal-regulatory protein beta-1 isoform 1, is a type I transmembrane protein of SIRP superfamily. It is an immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein also participates in the recruitment of tyrosine kinase SYK. And it acts as an activating isoform of SIRP alpha molecules that recruit SHP-1 and SHP-2 protein tyrosine phosphatases and activate counterparts, whose engagement couples to protein tyrosine kinases.
• Form: Liquid
• Molecular Mass: 38.0 kDa
• N-terminal Sequence Analysis: Glu 30
• Endotoxin: < 1.0 EU per 1 μg of protein (determined by LAL method)
• Purity: > 90% by SDS - PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/mL (determined by Absorbance at 280nm)
• Storage Buffer: In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
• Warning: For research use only. This product is not intended or approved for human, diagnostics or veterin
• AA Sequence: EDELQVIQPEKSVSVAAGESATLRCAMTSLIPVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLDFSISISNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTRGDVHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPRGLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEHDGQQAVSKSYALEISAHQKEHGSDITHEAALAPTAPLHHHHHH

Gene Information

• Gene Name: SIRPB1 signal regulatory protein beta 1 [ Homo sapiens (human) ]
• Official Symbol: SIRPB1
• Synonyms: SIRPB1; signal regulatory protein beta 1; CD172b; SIRP-BETA-1; signal-regulatory protein beta-1; CD172 antigen-like family member B
• Gene ID: 10326
• mRNA Refseq: NM_006065
• Protein Refseq: NP_006056
• MIM: 603889
• UniProt ID: O00241