| Description : |
SIRPB1, also known as signal-regulatory protein beta-1 isoform 1, is a type I transmembrane protein of SIRP superfamily. It is an immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein also participates in the recruitment of tyrosine kinase SYK. And it acts as an activating isoform of SIRP alpha molecules that recruit SHP-1 and SHP-2 protein tyrosine phosphatases and activate counterparts, whose engagement couples to protein tyrosine kinases. |
| Source : |
Insect cell |
| Species : |
Human |
| Tag : |
His |
| Form : |
Liquid |
| Molecular Mass : |
38.0 kDa |
| AASequence : |
EDELQVIQPEKSVSVAAGESATLRC AMTSLIPVGPIMWFRGAGAGRELIY NQKEGHFPRVTTVSELTKRNNLDFS ISISNITPADAGTYYCVKFRKGSPD DVEFKSGAGTELSVRAKPSAPVVSG PAVRATPEHTVSFTCESHGFSPRDI TLKWFKNGNELSDFQTNVDPAGDSV SYSIHSTARVVLTRGDVHSQVICEI AHITLQGDPLRGTANLSEAIRVPPT LEVTQQPMRAENQANVTCQVSNFYP RGLQLTWLENGNVSRTETASTLIEN KDGTYNWMSWLLVNTCAHRDDVVLT CQVEHDGQQAVSKSYALEISAHQKE HGSDITHEAALAPTAPLHHHHHH |
| N-terminal Sequence Analysis : |
Glu 30 |
| Endotoxin : |
< 1.0 EU per 1 μg of protein (determined by LAL method) |
| Purity : |
> 90% by SDS - PAGE |
| Storage : |
Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
| Concentration : |
0.25 mg/mL (determined by Absorbance at 280nm) |
| Storage Buffer : |
In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Warning : |
For research use only. This product is not intended or approved for human, diagnostics or veterin |
